{"id":6431,"date":"2019-05-07T13:54:17","date_gmt":"2019-05-07T11:54:17","guid":{"rendered":"https:\/\/inovie.fr\/imagenome-v2\/?page_id=6431"},"modified":"2019-11-04T11:41:18","modified_gmt":"2019-11-04T10:41:18","slug":"en-savoir-plus","status":"publish","type":"page","link":"https:\/\/imagenome.fr\/biopathologie-genetique-des-cancers\/en-savoir-plus\/","title":{"rendered":"En savoir plus"},"content":{"rendered":"

La compr\u00e9hension des m\u00e9canismes g\u00e9nomiques impliqu\u00e9s dans l’apparition d’une cellule canc\u00e9reuse fait appel a des notions fondamentales de g\u00e9n\u00e9tique. Quelques d\u00e9finitions utiles pour vous guider.<\/p>\n

\n\t\t
\n\t\t\t

Glossaire<\/h2>\n\t\t\t
\n\t\t\t

ADN<\/a><\/h3>\n\t\t\t

L\u2019acide d\u00e9soxyribonucl\u00e9ique, ou ADN, est une macromol\u00e9cule biologique pr\u00e9sente dans les cellules sous forme de double brin en h\u00e9lice. Chaque brin est form\u00e9 par une succession de petites sous-unit\u00e9s appel\u00e9es \u2014 ad\u00e9nine (A), cytosine (C), guanine (G) ou thymine (T) L\u2019ordre dans lequel se succ\u00e8dent les sous-unit\u00e9s le long d\u2019un brin d\u2019ADN constitue la s\u00e9quence de ce brin. C\u2019est cette s\u00e9quence qui porte l\u2019information g\u00e9n\u00e9tique.<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t

\n\t\t\t

ADN Tumoral<\/a><\/h3>\n\t\t\t

C’est l\u2019ADN extrait des cellules canc\u00e9reuses. Il pr\u00e9sente de nombreuses anomalies comme les mutations.<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t

\n\t\t\t

Code G\u00e9n\u00e9tique<\/a><\/h3>\n\t\t\t

les sous-unit\u00e9s A-T-G-C de l\u2019ADN forment des groupes de 3 (codons) qui correspondent \u00e0 un acide amin\u00e9. Les prot\u00e9ines de la cellule sont synth\u00e9tis\u00e9es dans un ordre pr\u00e9cis d\u2019acides amin\u00e9s ainsi cod\u00e9 par l\u2019ADN.<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t

\n\t\t\t

G\u00e8ne<\/a><\/h3>\n\t\t\t

La s\u00e9quence d\u2019ADN qui sert \u00e0 coder pour la synth\u00e8se de prot\u00e9ines.<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t

\n\t\t\t

G\u00e9nome<\/a><\/h3>\n\t\t\t

Le g\u00e9nome est l\u2019ensemble du mat\u00e9riel g\u00e9n\u00e9tique d\u2019un individu cod\u00e9 dans son ADN.<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t

\n\t\t\t

Mutations<\/a><\/h3>\n\t\t\t

une anomalie dans l\u2019ordre des sous-unit\u00e9s ATGC s\u2019appelle une mutation. Elle peut entrainer une anomalie dans la synth\u00e8se des prot\u00e9ines.<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t

\n\t\t\t

S\u00e9quencage<\/a><\/h3>\n\t\t\t

ensembles de techniques de biologie mol\u00e9culaire permettant de conna\u00eetre l\u2019ordre des sous-unit\u00e9s ATGC de l\u2019ADN<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t

\n\t\t\t

Th\u00e9rapies Cibl\u00e9es<\/a><\/h3>\n\t\t\t

On appelle traitements ou th\u00e9rapies cibl\u00e9s des m\u00e9dicaments qui bloquent des m\u00e9canismes sp\u00e9cifiques des cellules canc\u00e9reuses.<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n","protected":false},"excerpt":{"rendered":"

La compr\u00e9hension des m\u00e9canismes g\u00e9nomiques impliqu\u00e9s dans l’apparition d’une cellule canc\u00e9reuse fait appel a des notions fondamentales de g\u00e9n\u00e9tique. Quelques d\u00e9finitions utiles pour vous guider.<\/p>\n","protected":false},"author":1,"featured_media":6419,"parent":6458,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-6431","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\nEn savoir plus - Imagenome<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/imagenome.fr\/biopathologie-genetique-des-cancers\/en-savoir-plus\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"En savoir plus - Imagenome\" \/>\n<meta property=\"og:description\" content=\"La compr\u00e9hension des m\u00e9canismes g\u00e9nomiques impliqu\u00e9s dans l’apparition d’une cellule canc\u00e9reuse fait appel a des notions fondamentales de g\u00e9n\u00e9tique. 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